Majority of experimental articles published in dental literature comprise of in-vitro research. The results of in-vitro research form the basis of conducting clinical trials and more often in clinical decision-making. Experimental laboratory studies involving dental materials are similar to clinical trials in many aspects. These studies often involve human tissue, which comes with huge variability. Hence certain steps employed in conducting clinical trials can be extrapolated to experimental studies to address these variabilities. A reporting guideline would ensure uniform reporting across in-vitro studies. This will help in conducting effective systematic reviews and meta-analyses of specific topics, thus bringing out the best evidence. The checklist aims to optimise reproducibility of a reported study. It includes sections that were not previously reported in in-vitro studies such as sample size calculation, sample preparation and handling, randomisation and blinded assessment and improved reporting of statistical methods and results.


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